Chemodynamic therapy (CDT), as a new type of therapy, has received more and more attention in the field of tumor therapy in recent years. By virtue of the characteristics of weak acid and excess H2O2 in the tumor microenvironment, CDT uses Fenton or Fenton-like reaction to catalyze the transformation of H2O2 into strongly oxidizing •OH, resulting in increased intracellular oxidation stress for lipid oxidation, protein inactivation, or DNA damage, and finally inducing apoptosis of cancer cells. In particular, CDT has the advantage of tumor specificity. However, the therapeutic efficacy of CDT frequently depends on the catalytic efficiency of Fenton reaction, which needs the presence of sufficient H2O2 and catalytic metal ions. Relatively low concentration of H2O2 and lack of catalytic metal ions usually limited the final therapeutic effect. The combination of CDT with immunotherapy will be an effective means to improve the therapeutic effect. In this review paper, the recent progresses related to the nanomedicine for the combination of CDT and immunotherapy are summarized. Immunogenic death of tumor cells, immune checkpoint inhibitors, and stimulator of interferon genes (STING) activation as the main immunotherapy strategies to combine with CDT are discussed. Finally, the challenges and prospectives for the clinical translation and future development direction are discussed.

中文翻译：

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用于癌症化学动力学疗法和免疫疗法相结合的纳米医学

化学动力学疗法（CDT）作为一种新型疗法，近年来在肿瘤治疗领域受到越来越多的关注。CDT利用肿瘤微环境中弱酸和过量H2O2的特性，利用Fenton或类Fenton反应催化H2O2转化为强氧化性·OH，导致细胞内氧化应激增加，导致脂质氧化、蛋白质失活或DNA损伤，最终诱导癌细胞凋亡。尤其是CDT具有肿瘤特异性的优势。然而，CDT的治疗效果常常取决于芬顿反应的催化效率，该反应需要有足够的H2O2和催化金属离子的存在。相对较低浓度的 H2O2 和缺乏催化金属离子通常限制了最终的治疗效果。CDT与免疫治疗的结合将是提高治疗效果的有效手段。本文综述了CDT与免疫疗法联合的纳米医学的最新进展。讨论了肿瘤细胞的免疫原性死亡、免疫检查点抑制剂和干扰素基因刺激剂（STING）激活作为与 CDT 结合的主要免疫治疗策略。最后，讨论了临床转化的挑战和前景以及未来的发展方向。