Parkinson's disease (PD), and other parkinsonian syndromes are known to cause striatonigral dopaminergic system dysfunction and autonomic disturbances, including the vasomotor and sudomotor nervous systems. The detection of I-FP-CIT SPECT (DaT scan) imaging and autonomic dysfunction helps differentiate PD from multiple system atrophy (MSA) and progressive supranuclear palsy (PSP). The sympathetic skin response (SSR) is a simple, non-invasive electrophysiological test that assesses the sympathetic sudomotor nervous system. It is reported that the SSR is impaired in patients with PD, MSA, and PSP. To study the relationship between SSR, I-metaiodobenzylguanidine (MIBG) cardiac scintigraphy and DaT scan imaging parameters in patients with PD, MSA, and PSP. The study included 62, 25, and 19 patients with PD, MSA, and PSP, respectively. The SSR, MIBG cardiac scintigraphy, and DaT scan imaging were examined. The amplitude and latency of the SSR were measured in all limbs and were compared with the results of MIBG cardiac scintigraphy and DAT scan imaging. The SSR amplitudes were lower than reported normal subjects' reference values in PD, MSA, and PSP. The SSR amplitude only correlated with MIBG cardiac scintigraphy and DaT scan imaging parameters in PD. Multiple regression analyses also showed a significant relationship between the amplitudes of SSR and DaT scan imaging in PD. Unlike MSA, and PSP, the sudomotor nervous system is parallelly involved with cardiac sympathetic and central dopaminergic dysfunction from the early stage of PD.

中文翻译：

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帕金森病中交感皮肤反应、123I-MIBG 闪烁扫描和 123I-FP-CIT SPECT 的相关性

已知帕金森病 (PD) 和其他帕金森综合症会导致纹状体黑质多巴胺能系统功能障碍和自主神经紊乱，包括血管舒缩和催汗神经系统。I-FP-CIT SPECT (DaT 扫描) 成像和自主神经功能障碍的检测有助于区分 PD 与多系统萎缩 (MSA) 和进行性核上性麻痹 (PSP)。交感皮肤反应 (SSR) 是一种简单、无创的电生理测试，可评估交感催汗神经系统。据报道，PD、MSA 和 PSP 患者的 SSR 受损。研究 PD、MSA 和 PSP 患者的 SSR、I-间碘苄基胍 (MIBG) 心脏闪烁扫描和 DaT 扫描成像参数之间的关系。该研究分别包括 62 名、25 名和 19 名患有 PD、MSA 和 PSP 的患者。检查了 SSR、MIBG 心脏闪烁扫描和 DaT 扫描成像。测量所有肢体的 SSR 幅度和潜伏期，并与 MIBG 心脏闪烁扫描和 DAT 扫描成像的结果进行比较。在 PD、MSA 和 PSP 中，SSR 幅度低于报告的正常受试者的参考值。SSR 幅度仅与 PD 中的 MIBG 心脏闪烁扫描和 DaT 扫描成像参数相关。多元回归分析还显示，PD 中 SSR 振幅和 DaT 扫描成像之间存在显着关系。与 MSA 和 PSP 不同，从 PD 的早期阶段起，催汗神经系统就同时涉及心脏交感神经和中枢多巴胺能功能障碍。