IntroductionProhibited drugs in unregulated markets may be adulterated, resulting in increased risks for people who use drugs. This study investigated levels of drug adulteration and substitution of drugs purchased in Australia from cryptomarkets.MethodsData were collected from a darknet forum called Test4Pay from 1 September 2022 to 23 August 2023. Posts were included if they reported the results of drug samples submitted by post to the Vancouver‐based Get Your Drugs Tested service, which uses Fourier‐transform infrared spectroscopy with immunoassay strip tests (fentanyl and benzodiazepines).ResultsOf 103 samples, 65% contained only the advertised substance, 14% contained the advertised substance in combination with other psychoactive and/or potentially harmful substances and for 21%, the advertised substance was absent. Substances sold as MDMA, methamphetamine or heroin were consistently found to contain only the advertised substance, while substances sold as 2C‐B, alprazolam or ketamine were the most likely to be completely substituted. Only 4 samples sold as cocaine contained solely the advertised substance, with 13 containing cocaine with adulterants like lidocaine, creatine, levamisole and boric acid (n = 19). No fentanyl contamination was detected. Novel dissociatives and novel benzodiazepines were detected, as well as a nitazene compound.Discussion and ConclusionsDrug markets under prohibition continue to contain numerous unexpected substances, some of which can elevate risk of harm. Cryptomarkets are not immune to this problem, despite review systems, which should, in theory, make vendors more accountable for the quality of their stock. These findings demonstrate a need for expansion of local drug checking services in Australia.

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在澳大利亚从加密市场购买的药品的掺假和替代：对 Test4Pay 的分析

简介不受监管的市场中的违禁药物可能会掺假，从而导致吸毒者的风险增加。这项研究调查了澳大利亚从加密市场购买的药物掺假和替代水平。方法数据是从 2022 年 9 月 1 日至 2023 年 8 月 23 日从名为 Test4Pay 的暗网论坛收集的。位于温哥华的 Get Your Drugs Tested 服务，该服务使用傅里叶变换红外光谱法和免疫检测试纸条测试（芬太尼和苯二氮卓类药物）。结果在 103 个样品中，65% 仅含有广告物质，14% 含有广告物质与其他精神活性物质的组合和/或潜在有害物质，21% 的人不存在广告中的物质。以 MDMA、甲基苯丙胺或海洛因出售的物质始终被发现仅含有广告中的物质，而以 2C-B、阿普唑仑或氯胺酮出售的物质最有可能被完全替代。只有 4 个以可卡因出售的样品仅含有广告中的物质，其中 13 个样品含有可卡因和利多卡因、肌酸、左旋咪唑和硼酸等掺假物。n= 19）。未检测到芬太尼污染。检测到新型解离剂和新型苯二氮卓类药物，以及硝氮化合物。讨论和结论禁止的药品市场仍然含有许多意想不到的物质，其中一些物质可能会增加伤害风险。尽管有审查系统，理论上应该让供应商对其库存质量更加负责，但加密货币市场也不能幸免于这个问题。这些发现表明需要扩大澳大利亚当地的药物检查服务。