IntroductionMelanoma guidelines stem largely from data on non‐Hispanic White (NHW) patients. We aimed to identify features of melanoma within non‐Hispanic Black (NHB) patients to inform strategies for earlier detection and treatment.MethodsFrom 2004 to 2019 Surveillance, Epidemiology, and End Results (SEER) data, we identified nonmetastatic melanoma patients with known TN category and race. Kaplan–Meier cancer‐specific survival (CSS) estimates and multivariable Cox proportional hazard modeling analyses were performed.ResultsOf 492 597 patients, 1499 (0.3%) were NHB, who were younger (21% vs. 17% age <50) and more commonly female (54% vs. 41%) than NHW, both p < 0.0005. For NHBs, lower extremity was the most common site (52% vs. 15% for NHWs, p < 0.0001), T category was higher (55% Tis–T1 vs. 82%; 27% T3–T4 vs. 8%, p < 0.0001) and stage at presentation was higher (19% Stage III, vs. 6%, p < 0.0001). Within the NHB cohort, males were older, and more often node‐positive than females. Five‐year Stage III CSS was 42% for NHB males versus 71% for females, adjusting for age and clinical nodal status (hazard ratio 2.48).ConclusionsNHB melanoma patients presented with distinct tumor characteristics. NHB males with Stage III disease had inferior CSS. Focus on this high‐risk patient cohort to promote earlier detection and treatment may improve outcomes.

中文翻译：

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黑人患者黑色素瘤的独特表现可能会为改善结果的策略提供信息

简介黑色素瘤指南主要源自非西班牙裔白人 (NHW) 患者的数据。我们的目的是确定非西班牙裔黑人 (NHB) 患者中黑色素瘤的特征，为早期检测和治疗策略提供信息。方法通过 2004 年至 2019 年的监测、流行病学和最终结果 (SEER) 数据，我们确定了具有已知 TN 类别的非转移性黑色素瘤患者和比赛。进行了 Kaplan-Meier 癌症特异性生存 (CSS) 估计和多变量 Cox 比例风险模型分析。结果 在 492 597 名患者中，1499 名 (0.3%) 为 NHB，他们年龄较小（21% vs. 17% 年龄 <50 岁）及以上女性比例普遍高于 NHW（分别为 54% 和 41%）p< 0.0005。对于 NHB，下肢是最常见的部位（NHW 为 52%，而 NHW 为 15%，p< 0.0001)，T 类别较高（55% Tis–T1 vs. 82%；27% T3–T4 vs. 8%，p< 0.0001）并且就诊时的分期更高（19% 为 III 期，而 6%，p< 0.0001)。在 NHB 队列中，男性比女性年龄更大，且淋巴结阳性的情况更常见。根据年龄和临床淋巴结状态进行调整后，NHB 男性的五年 III 期 CSS 为 42%，而女性为 71%（风险比 2.48）。结论 NHB 黑色素瘤患者呈现出独特的肿瘤特征。患有 III 期疾病的 NHB 男性 CSS 较差。关注这一高危患者群体，促进早期发现和治疗可能会改善结果。