RNA-binding proteins (RBPs) are kinds of proteins with either singular or multiple RNA-binding domains (RBDs), and they can assembly into ribonucleic acid–protein complexes, which mediate transportation, editing, splicing, stabilization, translational efficiency, or epigenetic modifications of their binding RNA partners, and thereby modulate various physiological and pathological processes. CUG-BP, Elav-like family 1 (CELF1) is a member of the CELF family of RBPs with high affinity to the GU-rich elements in mRNA, and thus exerting control over critical processes including mRNA splicing, translation, and decay. Mounting studies support that CELF1 is correlated with occurrence, genesis and development and represents a potential therapeutical target for these malignant diseases. Herein, we present the structure and function of CELF1, outline its role and regulatory mechanisms in varieties of homeostasis and diseases, summarize the identified CELF1 regulators and their structure–activity relationships, and prospect the current challenges and their solutions during studies on CELF1 functions and corresponding drug discovery, which will facilitate the establishment of a targeted regulatory network for CELF1 in diseases and advance CELF1 as a potential drug target for disease therapy.

中文翻译：

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CUG 结合蛋白 1 (CELF1) 在稳态和疾病中的简历：系统评价

RNA结合蛋白（RBP）是具有单个或多个RNA结合域（RBD）的蛋白质，它们可以组装成核糖核酸-蛋白质复合物，介导运输、编辑、剪接、稳定、翻译效率或表观遗传修饰其结合RNA伴侣，从而调节各种生理和病理过程。CUG-BP，Elav 样家族 1 (CELF1) 是 RBP CELF 家族的成员，与 mRNA 中富含 GU 的元件具有高亲和力，从而控制 mRNA 剪接、翻译和衰变等关键过程。越来越多的研究表明CELF1与发生、发生和发展相关，是这些恶性疾病的潜在治疗靶点。在此，我们介绍了CELF1的结构和功能，概述了其在多种稳态和疾病中的作用和调节机制，总结了已识别的CELF1调节因子及其构效关系，并展望了当前CELF1功能和疾病研究中面临的挑战和解决方案。相应的药物发现，将有助于建立CELF1在疾病中的靶向调控网络，并推动CELF1作为疾病治疗的潜在药物靶点。