Perfluorooctane sulfonate (PFOS) exerts adverse effects on neuronal development in young population. Limited evidences have shown that early-life PFOS exposure holds a potential risk for developing age-related neurodegenerative diseases such as Alzheimer’s disease later in life. The present study investigated the effects of lactational PFOS exposure on cognitive function using one-year-old mice. Dams were exposed to PFOS (1 mg/kg body weight) through lactation by gavage. Male offspring were used for the behavior test battery to assess cognitive function. Western blot analysis was conducted to measure the levels of proteins related to the pathogenesis of Alzheimer’s disease. PFOS-exposed mice displayed a mild deficiency in social recognition. In the hippocampus, the expression of tau protein was significantly increased. These results underline a mild effect of developing PFOS exposure on cognitive function and neurodegeneration. The present study presents the long-lasting effects of PFOS in middle-aged period and warrants a potential aftermath.

中文翻译：

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哺乳期接触全氟辛烷磺酸仍然是中年雄性小鼠脑功能的潜在风险

全氟辛烷磺酸（PFOS）对年轻人的神经元发育产生不利影响。有限的证据表明，生命早期接触全氟辛烷磺酸可能会导致晚年罹患与年龄相关的神经退行性疾病，例如阿尔茨海默病。本研究使用一岁小鼠研究了哺乳期 PFOS 暴露对认知功能的影响。母鼠在哺乳期间通过强饲法暴露于全氟辛烷磺酸（1 毫克/千克体重）。雄性后代被用于行为测试组以评估认知功能。进行蛋白质印迹分析来测量与阿尔茨海默病发病机制相关的蛋白质水平。暴露于全氟辛烷磺酸的小鼠表现出轻微的社会认知缺陷。在海马体中，tau蛋白的表达显着增加。这些结果强调了全氟辛烷磺酸暴露对认知功能和神经变性的轻微影响。本研究展示了全氟辛烷磺酸对中年时期的长期影响，并证明了潜在的后果。