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Suppressed IgG4 class switching in dupilumab- and TNF inhibitor-treated patients after mRNA vaccination
Allergy ( IF 12.4 ) Pub Date : 2024-03-04 , DOI: 10.1111/all.16089 Anika M. Valk 1, 2, 3 , Jim B. D. Keijser 1, 3 , Koos P. J. van Dam 4 , Eileen W. Stalman 4 , Luuk Wieske 4, 5 , Maurice Steenhuis 1 , Laura Y. L. Kummer 1, 3, 4 , Phyllis I. Spuls 6 , Marcel W. Bekkenk 6 , Annelie H. Musters 6 , Nicoline F. Post 6 , Angela L. Bosma 6 , Barbara Horváth 7 , Dirk‐Jan Hijnen 8 , Corine R. G. Schreurs 8 , Zoé L. E. van Kempen 9 , Joep Killestein 9 , Adriaan G. Volkers 10 , Sander W. Tas 11 , Laura Boekel 12 , Gerrit J. Wolbink 1, 12 , Sofie Keijzer 1, 3 , Ninotska I. L. Derksen 1, 3 , Melanie van Deelen 1 , Gerard van Mierlo 1, 3 , Taco W. Kuijpers 1, 3, 13 , Filip Eftimov 4 , S. Marieke van Ham 1, 2, 3 , Anja ten Brinke 1, 3 , Theo Rispens 1, 3 ,
Allergy ( IF 12.4 ) Pub Date : 2024-03-04 , DOI: 10.1111/all.16089 Anika M. Valk 1, 2, 3 , Jim B. D. Keijser 1, 3 , Koos P. J. van Dam 4 , Eileen W. Stalman 4 , Luuk Wieske 4, 5 , Maurice Steenhuis 1 , Laura Y. L. Kummer 1, 3, 4 , Phyllis I. Spuls 6 , Marcel W. Bekkenk 6 , Annelie H. Musters 6 , Nicoline F. Post 6 , Angela L. Bosma 6 , Barbara Horváth 7 , Dirk‐Jan Hijnen 8 , Corine R. G. Schreurs 8 , Zoé L. E. van Kempen 9 , Joep Killestein 9 , Adriaan G. Volkers 10 , Sander W. Tas 11 , Laura Boekel 12 , Gerrit J. Wolbink 1, 12 , Sofie Keijzer 1, 3 , Ninotska I. L. Derksen 1, 3 , Melanie van Deelen 1 , Gerard van Mierlo 1, 3 , Taco W. Kuijpers 1, 3, 13 , Filip Eftimov 4 , S. Marieke van Ham 1, 2, 3 , Anja ten Brinke 1, 3 , Theo Rispens 1, 3 ,
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The noninflammatory immunoglobulin G4 (IgG4) is linked to tolerance and is unique to humans. Although poorly understood, prolonged antigenic stimulation and IL-4-signaling along the T helper 2-axis may be instrumental in IgG4 class switching. Recently, repeated SARS-CoV-2 mRNA vaccination has been linked to IgG4 skewing. Although widely used immunosuppressive drugs have been shown to only moderately affect humoral responses to SARS-CoV-2 mRNA vaccination, the effect on IgG4 switching has not been investigated.
中文翻译：
mRNA 疫苗接种后，接受 dupilumab 和 TNF 抑制剂治疗的患者的 IgG4 类别转换受到抑制
非炎症性免疫球蛋白 G4 (IgG4) 与耐受性有关，并且是人类独有的。尽管了解甚少，但沿 T 辅助细胞 2 轴的长时间抗原刺激和 IL-4 信号传导可能有助于 IgG4 类别转换。最近，重复的 SARS-CoV-2 mRNA 疫苗接种与 IgG4 偏差有关。尽管广泛使用的免疫抑制药物已被证明只能适度影响 SARS-CoV-2 mRNA 疫苗接种的体液反应，但其对 IgG4 转换的影响尚未得到研究。
更新日期：2024-03-05
中文翻译：
mRNA 疫苗接种后，接受 dupilumab 和 TNF 抑制剂治疗的患者的 IgG4 类别转换受到抑制
非炎症性免疫球蛋白 G4 (IgG4) 与耐受性有关，并且是人类独有的。尽管了解甚少，但沿 T 辅助细胞 2 轴的长时间抗原刺激和 IL-4 信号传导可能有助于 IgG4 类别转换。最近，重复的 SARS-CoV-2 mRNA 疫苗接种与 IgG4 偏差有关。尽管广泛使用的免疫抑制药物已被证明只能适度影响 SARS-CoV-2 mRNA 疫苗接种的体液反应，但其对 IgG4 转换的影响尚未得到研究。
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