This work evaluated the insecticidal, antifeedant and AChE inhibitory activity of compounds with eudesmane skeleton. The insecticidal activity was tested against larvae of and , the compounds and were the most active (LC of 104.2 and 106.7 μM; 82.0 and 84.4 μM, respectively). Likewise, the mentioned compounds were those that showed the highest acetylcholinesterase inhibitory activity, with IC of 0.26 ± 0.016 and 0.77 ± 0.016 μM, respectively. Enzyme kinetic studies, as well as molecular docking, show that the compounds would be non-competitive inhibitors of the enzyme. The antifeedant activity on larvae showed an antifeedant index (AI) of 99% at 72 h for compounds , and . The QSAR studies show that the properties associated with the polarity of the compounds would be responsible for the biological activities found.

中文翻译：

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桉树倍半萜类化合物的杀虫、拒食和乙酰胆碱酯酶抑制活性及其分子对接和 QSAR

本工作评价了具有桉烷骨架的化合物的杀虫、拒食和乙酰胆碱酯酶抑制活性。测试了 和 的幼虫杀虫活性，化合物 和 的活性最强（LC 分别为 104.2 和 106.7 μM；82.0 和 84.4 μM）。同样，上述化合物表现出最高的乙酰胆碱酯酶抑制活性，IC 值分别为 0.26 ± 0.016 和 0.77 ± 0.016 μM。酶动力学研究以及分子对接表明，这些化合物将是酶的非竞争性抑制剂。对幼虫的拒食活性显示，化合物 、 和 72 小时时的拒食指数 (AI) 为 99%。 QSAR 研究表明，与化合物极性相关的特性可能与所发现的生物活性有关。