In this study, we utilized the pulsed photoacoustic (PA) technique to analyze globular sedimentation in whole human blood, with a focus on distinguishing between healthy individuals and those with hemolytic anemia. Blood samples were collected from both healthy individuals (women and men) and those with hemolytic anemia, and temporal and spectral parameters of PA signals were employed for analysis. Significant differences (p < 0.05) were observed in PA metrics between the two groups. The proposed spectral analysis allowed significant differentiation within a 25-minute measurement window. Anemic blood samples exhibited higher erythrocyte sedimentation rate (ESR) values, indicating increased erythrocyte aggregation. This study underscores the potential of PA signal analysis in ESR assessment as an efficient method for distinguishing between healthy and anemic blood, surpassing traditional approaches. It represents a promising contribution to the development of precise and sensitive techniques for analyzing human blood samples in clinical settings.

中文翻译：

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通过光声信号分析研究人体血液中的红细胞沉降

在这项研究中，我们利用脉冲光声（PA）技术来分析人类全血中的球状沉降，重点是区分健康个体和溶血性贫血患者。从健康个体（女性和男性）和溶血性贫血患者采集血液样本，并采用 PA 信号的时间和光谱参数进行分析。两组之间的 PA 指标存在显着差异 (p < 0.05)。所提出的光谱分析可以在 25 分钟的测量窗口内实现显着的差异。贫血的血液样本表现出较高的红细胞沉降率（ESR）值，表明红细胞聚集增加。这项研究强调了 PA 信号分析在 ESR 评估中作为区分健康血液和贫血血液的有效方法的潜力，超越了传统方法。它对临床环境中分析人体血液样本的精确和灵敏技术的发展做出了有希望的贡献。