Depression stands as a prominent contributor to global disability, entailing an elevated risk of suicide. Substantial evidence supports the notion that immune dysregulation may play a role in the development of depression and impede responses to antidepressant treatments. Immune dysregulation may cause depression in susceptible individuals through raising inflammatory responses. Differences in immune cell types and the release of pro-inflammatory mediators are observed in the blood and cerebrospinal fluid of patients with major depressive disorder, which is associated with neuroimmune dysfunction. Therefore, the interaction of peripheral and central immune targets in depression needs to be understood. Urgent attention is required for the development of innovative therapeutics directed at modulating immune responses for the treatment of depression. This review delineates the immune mechanisms involved in the pathogenesis of depression, assesses the therapeutic potential of immune system targeting for depression treatment, and deliberates on the merits and constraints of employing immunotherapy in the management of depression.

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抑郁症的免疫疗法：最新见解和未来目标

抑郁症是导致全球残疾的一个重要因素，导致自杀风险升高。大量证据支持这样的观点，即免疫失调可能在抑郁症的发展中发挥作用，并阻碍抗抑郁治疗的反应。免疫失调可能会通过增强炎症反应而导致易感人群抑郁。在重度抑郁症患者的血液和脑脊液中观察到免疫细胞类型和促炎介质释放的差异，这与神经免疫功能障碍有关。因此，需要了解抑郁症中外周和中枢免疫靶点的相互作用。需要迫切关注开发旨在调节免疫反应来治疗抑郁症的创新疗法。这篇综述描述了抑郁症发病机制中涉及的免疫机制，评估了免疫系统靶向治疗抑郁症的治疗潜力，并探讨了在抑郁症治疗中采用免疫疗法的优点和限制。