Successful wound healing in diabetic patients is hindered by dysregulated miRNA expression. This study aimed to investigate the abnormal expression of miRNAs in diabetic wound healing and the potential therapeutic role of modulating the miR-206/HIF-1α pathway. MicroRNA assays were used to identify differentially expressed miRNAs in diabetic wound sites and adjacent areas. In vitro models and a rat diabetic model were established to evaluate the effects of miR-206 on HIF-1α regulation and wound healing. The study revealed differential expression of miR-206 in diabetic wound tissues, its interaction with HIF-1α, and the inhibitory effect of miR-206 on cell growth under high glucose conditions. Modulating the miR-206/HIF-1α pathway using miR-206 antagomir promoted HIF-1α, CD34, and VEGF expression, ultimately enhancing diabetic wound healing.

糖尿病患者伤口的成功愈合受到 miRNA 表达失调的阻碍。本研究旨在探讨 miRNA 在糖尿病伤口愈合中的异常表达以及调节 miR-206/HIF-1α 通路的潜在治疗作用。MicroRNA 测定用于识别糖尿病伤口部位和邻近区域中差异表达的 miRNA。建立体外模型和大鼠糖尿病模型来评估miR-206对HIF-1α调节和伤口愈合的影响。该研究揭示了糖尿病伤口组织中miR-206的差异表达、其与HIF-1α的相互作用以及miR-206在高糖条件下对细胞生长的抑制作用。使用 miR-206 antagomir 调节 miR-206/HIF-1α 通路可促进 HIF-1α、CD34 和 VEGF 表达，最终增强糖尿病伤口愈合。