Purpose

The aims of this study were to compare cerebral hemodynamics and maximal oxygen uptake (VO_2peak) in patients with end-stage renal disease (ESRD) vs. age-matched healthy controls during maximal exercise.

Methods

Twelve patients with ESRD and twelve healthy adults (CTR group) performed exhaustive incremental exercise test. Throughout the exercise test, near-infrared spectroscopy allowed the investigation of changes in oxyhemoglobin (∆O₂Hb), deoxyhemoglobin (∆HHb), and total hemoglobin (∆THb) in the prefrontal cortex.

Results

Compared to CTR, VO_2peak was significantly lower in ESRD group (P < 0.05). Increase in ∆THb (i.e., cerebral blood volume) was significantly blunted in ESRD (P < 0.05). ESRD patients also had impaired changes in cerebral ∆HHb and ∆O₂Hb during high intensity of exercise (P < 0.05). Finally, no significant correlation was observed between VO_2peak and changes in cerebral hemodynamics parameters in both groups (All P > 0.05).

Conclusion

Maximal exercise highlights subtle disorders of both hemodynamics and neuronal oxygenation in the prefrontal cortex in patients with ESRD. This may contribute to both impaired cognitive function and reduced exercise tolerance throughout the progression of the disease.

中文翻译：

---

终末期肾病患者对增量运动的脑血流动力学反应减弱

目的

本研究的目的是比较终末期肾病 (ESRD) 患者与年龄匹配的健康对照者在最大运动期间的_{脑血流动力学和最大摄氧量 (} VO 2peak )。

方法

12 名 ESRD 患者和 12 名健康成人（CTR 组）进行了详尽的增量运动测试。在整个运动测试中，近红外光谱可以研究前额皮质中氧合血红蛋白 (ΔO _{2 Hb)、脱氧血红蛋白 (ΔHHb) 和总血红蛋白 (ΔTHb) 的变化。}

结果

与 CTR 相比，ESRD 组V O _{2peak显着降低（} P  < 0.05）。ESRD 患者的 ΔTHb（即脑血容量）增加显着减弱（P  < 0.05）。ESRD 患者在高强度运动期间脑 ΔHHb 和 ΔO ₂ Hb的变化也受损（ P  < 0.05）。最后，两组VO _2peak与脑血流动力学参数变化均无显着相关性（均P  > 0.05）。

结论

最大程度的运动凸显了终末期肾病患者前额叶皮层血流动力学和神经元氧合的微妙紊乱。这可能会导致整个疾病进展过程中认知功能受损和运动耐量降低。