Estradiol mediates greater germinal center responses to influenza vaccination in female than male mice,mBio

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Estradiol mediates greater germinal center responses to influenza vaccination in female than male mice
mBio ( IF 6.4 ) Pub Date : 2024-03-05 , DOI: 10.1128/mbio.00326-24
Santosh Dhakal ₁ , Han-Sol Park ₁ , Kumba Seddu ₁ , John S. Lee ₁ , Patrick S. Creisher ₁ , Brittany Seibert ₁ , Kimberly M. Davis ₁ , Isabella R. Hernandez ₂ , Robert W. Maul ₂ , Sabra L. Klein ₁

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Females of reproductive ages develop greater antibody responses to influenza vaccines than males. We hypothesized that female-biased immunity and protection against influenza were mediated by estradiol signaling in B cells. Using diverse mouse models ...

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