Skin disorders are the most common apprehension worldwide among different regions of the world. Topical route of administration offers benefits over other routes such as avoidance of first‐pass metabolism, low dose, longer residence time, and absence of off‐target delivery. Skin serves as a mechanical barrier for therapeutic delivery with selectively permeable essential molecules. Considering the structural complexity of skin, delivery of therapeutics at targeted site requires sophisticated method such as nanotechnology‐assisted therapeutic delivery. The roadmap for combinatorial approach of nanotechnology and skin therapeutics has proven significant in clinical and marketed products. Currently, various pharmaceutical aids such as nanocrystal (NCs), nanoparticles, nanoemulsion, nano‐micelles, nano lipidic carriers, and hybrid nanocarriers are currently in market. Among all the other nanocarriers, nanocrystal offers precedence over other nanocarriers due to its facile method of preparation, reproducibility, low excipient concentration, and high therapeutic loading capacity. The recent literature data suggest the breakthrough evolution of NCs in topical therapeutic delivery. The outcome of these interventions envisages the applicability of NCs for delivering molecules with compromised physicochemical characteristics such as solubility, stability, toxicity, and bioavailability concerns.

中文翻译：

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纳米晶体：皮肤病的多方面治疗方案

皮肤病是世界不同地区最常见的忧虑。局部给药途径比其他途径具有优势，例如避免首过代谢、低剂量、更长的停留时间以及不存在脱靶递送。皮肤作为选择性渗透必需分子进行治疗传递的机械屏障。考虑到皮肤结构的复杂性，在目标部位递送治疗药物需要复杂的方法，例如纳米技术辅助的治疗递送。纳米技术和皮肤治疗组合方法的路线图已被证明在临床和上市产品中具有重要意义。目前，市场上有各种药物助剂，如纳米晶体（NC）、纳米颗粒、纳米乳剂、纳米胶束、纳米脂质载体和混合纳米载体。在所有其他纳米载体中，纳米晶体因其制备方法简便、重现性好、赋形剂浓度低和治疗负载能力高而优于其他纳米载体。最近的文献数据表明 NC 在局部治疗递送方面取得了突破性进展。这些干预措施的结果设想了NCs可用于递送具有受损的物理化学特性（例如溶解度、稳定性、毒性和生物利用度问题）的分子。