Background:In the reconstruction of large complex cutaneous wounds, a myriad of mechanical devices has been designed to facilitate primary wound closure. However, there is a dearth of studies elucidating how best to achieve optimum use and efficiency of skin stretching (SS) when using the device for immediate primary closure of defects.Methods:Skin defect wounds (7 × 7 cm) were prepared on the back of three Bama miniature pigs. A total of 15 cycles of SS (cycle loading) were subsequently performed on the skin edges of the wound by EASApprox® SS system. Then, the changes in equidistant points were recorded after each cycle. After the SS test, all wounds were sutured under low tension.Results:Skin elongation was observed at all equidistant points on the back wounds of three Bama miniature pigs. Up to an additional 1.10 to 3.75 cm of tissue was garnered. The maximum skin elongation was typically achieved within eight cycles of stretching and relaxation. Beyond this range, additional stretching cycles did not result in further skin extension.Conclusion:There may be a close link between mobilization range and the times of acute cyclic stretching (cycle loading) during the process of primary wound closure. However, larger studies are required to further evaluate the accuracy and effectiveness.

中文翻译：

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立即一期闭合大面积皮肤缺损的最佳周期是什么？

背景：在大型复杂皮肤伤口的重建中，设计了多种机械装置来促进初级伤口闭合。然而，缺乏研究来阐明在使用该装置立即初级闭合缺损时如何最好地实现皮肤拉伸 (SS) 的最佳使用和效率。方法：在背部准备皮肤缺损伤口（7 × 7 厘米）三只巴马小型猪。随后通过 EASAprox® SS 系统对伤口皮肤边缘进行总共 15 个循环的 SS（循环加载）。然后，在每个循环后记录等距点的变化。SS试验结束后，低张力缝合所有伤口。结果：3只巴马小型猪背部伤口所有等距点均观察到皮肤伸长。额外获得了 1.10 至 3.75 厘米的组织。最大皮肤伸长通常在八个拉伸和放松周期内实现。超出这个范围，额外的拉伸循环不会导致皮肤进一步伸展。结论：在初次伤口闭合过程中，活动范围与急性循环拉伸（循环负荷）的次数之间可能存在密切联系。然而，需要更大规模的研究来进一步评估准确性和有效性。