The polypill strategy, which combines several medicines that simultaneously control different risk factors/diseases in a single pill, is one of the approaches used in cardiovascular therapy. In different guidelines, this one-pill combination therapy is suggested as first-line step in disease management. Because the cardiovascular diseases (CVD) pandemia, prevention is essential. The approaches that could improve adherence are of great importance to achieve health, social and economical benefits. However, direct or indirect experience of adverse drug reaction is often the reason for discontinuation, with serious fatal and non-fatal consequences especially for a polypill. Angiotensin-converting enzyme inhibitors (ACEi) and statins are the most prescribed medications in CVD prevention. It is well known that both drugs may have adverse effects that induce discontinuation. Often, the personal awareness of these effects is a reason for self-discontinuation. In this study an analysis of the ACEi/statin awareness is reported. Is it potentially harmful for polypill?

中文翻译：

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血管紧张素转换酶抑制剂、他汀类药物和复方丸在心血管疾病预防中的作用：无知是福还是福？

复方药策略是将多种药物结合在一颗药丸中，同时控制不同的危险因素/疾病，是心血管治疗中使用的方法之一。在不同的指南中，这种单药联合疗法被建议作为疾病管理的一线步骤。由于心血管疾病（CVD）流行，预防至关重要。提高依从性的方法对于实现健康、社会和经济效益非常重要。然而，直接或间接经历的药物不良反应通常是停药的原因，特别是对于复方药来说，会产生严重的致命和非致命后果。血管紧张素转换酶抑制剂 (ACEi) 和他汀类药物是预防 CVD 中最常用的药物。众所周知，这两种药物都可能产生导致停药的不良反应。通常，个人对这些影响的认识是自我终止的原因。本研究报告了 ACEi/他汀类药物认知度的分析。它对复方药是否有潜在危害？