Compare adulthood socioeconomic status for children with and without a history of seizures. Retrospective cohort study using Aberdeen Children of the Nineteen Fifties (ACONF) data comprising children born 1950–1956 attending primary school 1962–1964, with follow-up data collected in 2001. Adulthood socioeconomic status was based on registrar general measure of occupational social class and categorised as high or low. We adjusted for potentially confounding variables including childhood socioeconomic status, behavioural issues (Rutter A/B scores), biological sex, school test scores, educational attainment, parental engagement with education, peer-status in school, and alcohol use in adulthood. A multivariate binary logistic regression was performed to estimate the adjusted association between children with a history of seizures of any type (for example febrile seizures, or provoked seizures of any other etiology or seizures in the context of epilepsy) or severity and adult socioeconomic status. Multiple imputation using the Monte-Carlo-Markov-Chain method accounted for missing data. Pooled estimates (N = 2,208) comparing children with a history of seizures (n = 81) and children without a history of seizures (n = 2,127) found no differences between these cohorts in terms of adulthood socioeconomic status in both unadjusted (Odds Ratio (OR) 1.45 [95 % CI 0.71–2.96], p = 0.31) and adjusted (1.02 [0.46, 2.24], p = 0.96) analyses. Compared to males, females were at increased odds of having a lower socioeconomic status in adulthood (1.56 [1.13–2.17], p = 0.01).Compared to those with low educational attainment, those with moderate (0.32 [0.21, 0.48], p < 0.001) and high (0.12 [0.07, 0.20], p < 0.001) educational attainment were at reduced odds of having a lower socioeconomic status in adulthood. Cognitive problems in childhood (using educational attainment and scores on primary school tests proxy markers for cognition) rather than a history of seizures per se, were associated with lower SES in a population of adults born 1950–56 in Aberdeen. This relationship may be different depending on the time in history and nation/region of study. Given the changes in health, education and social support in the management of children with seizures over time, it would be of interest to investigate outcomes in a contemporary cohort. Such studies should ideally have validated diagnoses of seizures, details on seizure characteristics such as seizure type and severity, and a large sample size using national data.

中文翻译：

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有或无癫痫病史的儿童成年后的社会经济状况：一项回顾性队列研究

比较有和没有癫痫病史的儿童成年后的社会经济状况。使用阿伯丁十九世纪五十年代儿童 (ACONF) 数据进行的回顾性队列研究，包括 1950 年至 1956 年出生、1962 年至 1964 年上小学的儿童，以及 2001 年收集的后续数据。成年社会经济地位基于登记员对职业社会阶层的一般衡量和分为高或低。我们调整了潜在的混杂变量，包括儿童社会经济地位、行为问题（拉特 A/B 分数）、生物性别、学校考试成绩、教育程度、父母对教育的参与、在学校的同龄人地位以及成年后的饮酒情况。进行多变量二元逻辑回归来估计有任何类型癫痫发作史（例如热性癫痫发作，或任何其他病因诱发的癫痫发作或癫痫背景下的癫痫发作）或严重程度与成人社会经济状况之间的调整关联。使用蒙特卡洛马尔可夫链方法的多重插补解释了缺失数据。对有癫痫病史的儿童 (n = 81) 和没有癫痫病史的儿童 (n = 2,127) 进行汇总估计 (N = 2,208) 比较，发现这些群体在成年社会经济状况方面没有差异（优势比 ( OR) 1.45 [95 % CI 0.71–2.96], p = 0.31) 和调整 (1.02 [0.46, 2.24], p = 0.96) 分析。与男性相比，女性成年后社会经济地位较低的几率更高（1.56 [1.13–2.17]，p = 0.01）。与受教育程度较低的人相比，中等教育程度的人（0.32 [0.21，0.48]，p = 0.01） < 0.001) 和高 (0.12 [0.07, 0.20], p < 0.001) 教育程度在成年后社会经济地位较低的几率较低。 1950-56 年出生于阿伯丁的成年人群体中，社会经济地位较低与童年时期的认知问题（使用教育程度和小学测试成绩作为认知的代理标记）而非癫痫病史本身有关。这种关系可能会根据历史时期和研究国家/地区的不同而有所不同。鉴于随着时间的推移，癫痫儿童治疗中的健康、教育和社会支持发生了变化，研究当代队列的结果将是有意义的。理想情况下，此类研究应包含经过验证的癫痫发作诊断、癫痫发作类型和严重程度等癫痫发作特征的详细信息，以及使用国家数据的大样本量。