In this study, the electrochemical properties of etofenamate, an active ingredient belonging to the non-steroidal anti-inflammatory drug group, were investigated using cyclic voltammetry (CV) and square wave voltammetry (SW) techniques on a disposable pencil graphite electrode (PGE). With the CV technique, reversible voltammetric waves of around +0.470 V and irreversible voltammetric waves of around +1.02 V were produced on the PGE. An environmentally friendly, selective and highly sensitive SW voltammetric method was developed using disposable PGE. This voltammetric method gave very good analytical working range on PGE in PBS (pH = 3.0) medium at concentrations ranging from 0.017 μM to 0.306 μM. The LOD value of this analytical method in PBS (pH = 3.0) medium was calculated as 0.0011 μM (0.406 μg L). The developed voltammetric method was successfully applied to urine and drug samples. The results of the voltammetric method were compared with the results of the spectrophotometric method. The results were found to be compatible with each other.

中文翻译：

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首次使用一次性石墨电极伏安技术进行电化学研究和测定非甾体抗炎药依托芬那酯

在这项研究中，使用循环伏安法（CV）和方波伏安法（SW）技术在一次性铅笔石墨电极（PGE）上研究了属于非甾体抗炎药组的活性成分依托芬那酯的电化学性质。 。利用CV技术，在PGE上产生约+0.470V的可逆伏安波和约+1.02V的不可逆伏安波。使用一次性 PGE 开发了一种环保、选择性和高灵敏度的 SW 伏安法。这种伏安法对 PBS (pH = 3.0) 介质中浓度范围为 0.017 μM 至 0.306 μM 的 PGE 提供了非常好的分析工作范围。该分析方法在 PBS (pH = 3.0) 培养基中的 LOD 值经计算为 0.0011 μM (0.406 μg·L)。所开发的伏安法已成功应用于尿液和药物样品。将伏安法的结果与分光光度法的结果进行比较。发现结果相互兼容。