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The infection of Cysticercus fasciolaris in natural rats (Rattus species) residing in human residence areas, Nakhon Si Thammarat, Thailand
Comparative Immunology, Microbiology and Infectious Diseases ( IF 2 ) Pub Date : 2024-03-01 , DOI: 10.1016/j.cimid.2024.102152
Sunsaneeya Thaikoed , Watcharapong Mitsuwan , Kittipong Chaisiri , Noppharat Tanthanathipchai , Maria de Lourdes Pereira , Alok K. Paul , Veeranoot Nissapatorn , Phirabhat Saengsawang

() is the larval stage of a cestode parasite named (). is found in small rodents, especially rats. species are listed as intermediate hosts of this parasite, and cats are the main definitive host of The objective of this study was to study the pathological, microscopic, and molecular aspects of in rodents residing in human residence areas. One hundred and two rodents were trapped in human settlements and dissected for larva-containing cyst examinations in the body cavity. The larvae of were investigated using histopathological examination, microscopic observations under a stereomicroscope and scanning electron microscope, and molecular detection using polymerase chain reaction. The prevalence of hepatic cysts containing larvae was 8.91% (95% CI = 4.16–16.24). In addition, the older larvae also had longer micropapillae. Histopathological investigation revealed normal hepatic tissue containing larvae and a scanty fluid cyst. The cyst capsule contains mostly mononuclear cells and spindle cells in all infected rats. The molecular detection using two primer sets revealed the amplicons were similar to the clade of . In the future, more investigation is necessary to fully understand the parasite's molecular pathogenesis and virulent molecules, which are less obvious.

中文翻译:

泰国洛坤府人类居住区自然老鼠(黄鼠属)感染带状囊尾蚴

() 是名为 () 的绦虫寄生虫的幼虫阶段。存在于小型啮齿动物,尤其是大鼠中。物种被列为这种寄生虫的中间宿主,而猫是这种寄生虫的主要终宿主。这项研究的目的是研究居住在人类居住区的啮齿动物的病理、微观和分子方面。一百零两只啮齿动物被困在人类住区中并被解剖以进行体腔内含有幼虫的包囊检查。通过组织病理学检查、立体显微镜和扫描电子显微镜下的显微观察以及聚合酶链式反应的分子检测来研究幼虫。含有幼虫的肝囊肿的患病率为 8.91% (95% CI = 4.16–16.24)。此外,较老的幼虫也有更长的微乳头。组织病理学检查显示正常肝组织含有幼虫和少量液囊。所有感染大鼠的囊肿包膜主要含有单核细胞和梭形细胞。使用两个引物组的分子检测显示扩增子与 的进化枝相似。未来,需要更多的研究来充分了解寄生虫的分子发病机制和毒力分子,而这些分子不太明显。
更新日期:2024-03-01
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