This review is an informative and constructive resource for researchers interested in the synthesis of -carbolines. It provides a comprehensive overview of the various synthetic pathways used between and for the aromatization of tetrahydro -carbolines (THC) to -carbolines (C). The focus is on recent advancements in oxidation, decarboxylation, dehydrogenation, and aromatization techniques using various reagents, and their potential in natural product synthesis. The review includes detailed information on reagents, reaction conditions, product yields, and reagent availability. The described methods can be used to synthesize numerous -carboline derivatives, which can be explored for the development of novel drug candidates and potential -carboline scaffolds like , etc. The -carboline structure is found in many natural alkaloids. These alkaloids and their derivatives have been shown to possess significant biological properties, which makes them promising candidates for the development of new drugs. The review also provides a helpful analysis of the advantages and disadvantages of the reagents used.

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更新：THβC 氧化芳构化为 β-咔啉及其在 β-咔啉生物碱合成中的应用

这篇综述为对 β-咔啉合成感兴趣的研究人员提供了信息丰富且具有建设性的资源。它全面概述了四氢咔啉 (THC) 芳构化至 咔啉 (C) 之间和用于芳构化的各种合成途径。重点是使用各种试剂的氧化、脱羧、脱氢和芳构化技术的最新进展及其在天然产物合成中的潜力。该评论包括有关试剂、反应条件、产品收率和试剂可用性的详细信息。所描述的方法可用于合成多种β-咔啉衍生物，这些衍生物可用于开发新的候选药物和潜在的-咔啉支架等。β-咔啉结构存在于许多天然生物碱中。这些生物碱及其衍生物已被证明具有显着的生物学特性，这使它们成为开发新药的有希望的候选者。该评论还对所用试剂的优缺点进行了有益的分析。