Altered brain network profiles in schizophrenia (SCZ) during memory consolidation are typically observed during task- periods such as encoding or retrieval. However active processes are also sub served by periods of memory consolidation. These periods active in that they allow memories to be recapitulated even in the absence of overt sensorimotor processing. It is plausible that regions central to memory formation like the dlPFC and the hippocampus, exert network signatures during covert periods. Are these signatures altered in patients? The question is clinically relevant because real world learning and memory is facilitated by covert processing, and may be impaired in schizophrenia. Here, we compared network signatures of the dlPFC and the hippocampus during covert periods of a learning and memory task. Because behavioral proficiency increased non-linearly, functional connectivity of the dlPFC and hippocampus [psychophysiological interaction (PPI)] was estimated for each of the Early (linear increases in performance) and Late (asymptotic performance) covert periods. During Early periods, we observed hypo-modulation by the hippocampus but hyper-modulation by dlPFC. Conversely, during Late periods, we observed hypo-modulation by the dlPFC and the hippocampus. We stitch these results into a conceptual model of network deficits during covert periods of memory consolidation.

中文翻译：

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隐性记忆巩固在精神分裂症中的重要性：海马体和背外侧前额叶皮层功能失调的网络特征

精神分裂症（SCZ）在记忆巩固过程中大脑网络轮廓的改变通常在编码或检索等任务期间观察到。然而，活动进程也受到内存整合周期的影响。这些时期很活跃，因为即使没有明显的感觉运动处理，它们也可以重述记忆。 dlPFC 和海马体等记忆形成的核心区域可能在隐秘时期发挥网络特征。患者的这些特征是否发生改变？这个问题具有临床相关性，因为现实世界的学习和记忆是通过秘密处理来促进的，并且在精神分裂症中可能会受到损害。在这里，我们比较了学习和记忆任务的隐蔽时期 dlPFC 和海马体的网络特征。由于行为熟练程度非线性增加，因此对每个早期（性能线性增加）和晚期（渐近性能）隐蔽期的 dlPFC 和海马体 [心理生理相互作用 (PPI)] 的功能连接进行了估计。在早期，我们观察到海马体调节不足，但 dlPFC 调节过度。相反，在晚期，我们观察到 dlPFC 和海马体的低调节。我们将这些结果缝合到记忆巩固的隐蔽时期网络缺陷的概念模型中。