The direct ink writing technique used in 3D printing technology is generally applied to designing biomedical hydrogels. Herein, we proposed a strategy for preparing all-chitin-based inks for wound dressing via direct ink writing technique. The β-chitin nanofibers (MACNF) with a high aspect ratio were applied as a nanofiller to modulate the rheological properties of the alkaline dissolved chitin solution. The printing fidelity significantly depends on the MACNF introduction amount to the composite ink. 5–10 wt% MACNF ratio showed superior printing performance. The printed scaffold showed a uniform micron-sized pore structure and a woven network of nanofibers. Due to the good biocompatibility of chitin and the stereoscopic spatial skeleton, this scaffold showed excellent performance as a wound dressing, which can promote cell proliferation, collagen deposition and the angiogenesis of wounds, demonstrating its potential in biomedical applications. This approach successfully balanced the chitinous printability and biofunctions.

中文翻译：

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甲壳素纳米原纤维辅助3D打印全甲壳素水凝胶用于伤口敷料

3D打印技术中使用的直接墨水书写技术通常应用于生物医学水凝胶的设计。在此，我们提出了一种通过直接墨水书写技术制备用于伤口敷料的全甲壳素墨水的策略。具有高长径比的β-甲壳素纳米纤维（MACNF）被用作纳米填料来调节碱溶解的甲壳素溶液的流变性能。印刷保真度很大程度上取决于复合油墨中 MACNF 的引入量。 5–10 wt% MACNF 比例显示出优异的印刷性能。打印的支架显示出均匀的微米级孔隙结构和纳米纤维编织网络。由于甲壳素良好的生物相容性和立体空间骨架，该支架作为伤口敷料表现出优异的性能，可以促进伤口的细胞增殖、胶原沉积和血管生成，展示了其在生物医学应用中的潜力。这种方法成功地平衡了几丁质的可印刷性和生物功能。