Injectable hydrogels have wide applications in clinical practice. However, the development of tough and bioadhesive ones based on biopolymers, along with biofriendly and robust crosslinking strategies, still represents a great challenge. Herein, we report an injectable hydrogel composed of maleimidyl alginate and pristine gelatin, for which the precursor solutions could self-crosslink via mild Michael-type addition without any catalyst or external energy upon mixing. This hydrogel is tough and bioadhesive, which can maintain intactness as well as adherence to the defect of porcine skin under fierce bending and twisting, warm water bath, and boiling water shower. Besides, it is biocompatible, bioactive and biodegradable, which could support the growth and remodeling of cells by affording an extracellular matrix-like environment. As a proof of application, we demonstrate that this hydrogel could significantly accelerate diabetic skin wound healing, thereby holding great potential in healthcare.

中文翻译：

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由马来酰亚胺基海藻酸盐和原始明胶形成的坚韧且具有生物粘附性的可注射水凝胶

可注射水凝胶在临床实践中具有广泛的应用。然而，开发基于生物聚合物的坚韧和生物粘附性材料，以及生物友好和强大的交联策略，仍然是一个巨大的挑战。在此，我们报道了一种由马来酰亚胺基海藻酸盐和原始明胶组成的可注射水凝胶，其前体溶液可以通过温和的迈克尔型加成自交联​​，无需任何催化剂或外部能量混合。这种水凝胶坚韧且具有生物粘附性，在剧烈弯曲和扭曲、温水浴、沸水淋浴下仍能保持猪皮肤缺损的完整性和粘附性。此外，它具有生物相容性、生物活性和可生物降解性，可以通过提供细胞外基质样环境来支持细胞的生长和重塑。作为应用证明，我们证明这种水凝胶可以显着加速糖尿病皮肤伤口的愈合，从而在医疗保健方面具有巨大的潜力。