This research aims to improve antimicrobial materials based on functional silica nanoparticles. Three different methods were used in the study to create silica nanoparticles with other properties. The nanoparticles’ morphological structures are porous, hollow, and filled with spherical forms. The surface of these nanoparticles was grafted with poly(1-vinyl-1,2,4-triazole) (PVTri). The morphological properties of nanocomposites were used for analysis. In contrast, thermal gravimetric analysis was used to characterize the thermal properties of nanocomposites (thermogravimetric analysis). The silica nanoparticles were evaluated for their in vitro antimicrobial activity against Escherichia coli, Staphylococcus aureus, and Saccharomyces cerevisiae using minimum inhibitory concentration measurement. Silica nanoparticles have different antifungal and antibacterial properties related to their structure. The cytotoxic effects of the silica nanoparticles on HaCaT cells were performed with an MTS assay. In this study, we observed that high doses of HSS and e-SiO₂ decreased cell growth, while HSS and e-SiO₂ composite with PVTri increased cell proliferation.

中文翻译：

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用支化聚（1-乙烯基-1,2,4-三唑）功能化的差别二氧化硅纳米粒子：抗菌、抗真菌和细胞毒性特性

本研究旨在改进基于功能性二氧化硅纳米粒子的抗菌材料。研究中使用了三种不同的方法来制造具有其他特性的二氧化硅纳米粒子。纳米颗粒的形态结构是多孔的、中空的并且填充有球形。这些纳米粒子的表面接枝有聚（1-乙烯基-1,2,4-三唑）（PVTri）。纳米复合材料的形态特性用于分析。相比之下，热重分析用于表征纳米复合材料的热性能（热重分析）。使用最小抑菌浓度测量来评估二氧化硅纳米粒子对大肠杆菌、金黄色葡萄球菌和酿酒酵母的体外抗菌活性。二氧化硅纳米颗粒具有与其结构相关的不同抗真菌和抗菌特性。通过 MTS 测定检测二氧化硅纳米粒子对 HaCaT 细胞的细胞毒性作用。在这项研究中，我们观察到高剂量的HSS和e-SiO ₂会降低细胞生长，而HSS和e-SiO ₂与PVTri的复合物会增加细胞增殖。