Purpose: Venous thromboembolism (VTE) poses a significant threat to individuals’ health, yet its correlation with mental disorders remains underappreciated. Here, we conducted a retrospective analysis to explore the characteristics of psychiatric patients presenting with VTE.
Methods: We retrospectively analyzed psychiatric inpatients with elevated plasma D-dimer levels at the Mental Health Center, First Affiliated Hospital, Zhejiang University School of Medicine, from January 2014 to January 2022. The inclusion criteria comprised comprehensive demographic and clinical profiles, including laboratory and imaging findings.
Results: A cohort of 33 eligible patients was included, with plasma D-dimer levels ranging from 880 to 10,700 μg/L FEU. Significantly higher D-dimer levels were observed in patients diagnosed with severe mental disorders (SMD), such as schizophrenia and bipolar disorder, compared to those with mild mental disorders (MMD), including depression and anxiety disorders (p = 0.007). Furthermore, individuals receiving antipsychotic medications for less than one year exhibited elevated D-dimer levels compared to those on treatment for over one year (p = 0.005). However, normalization of D-dimer levels did not demonstrate a significant association with psychiatric diagnosis or treatment duration (p > 0.05).
Conclusion: Our findings suggest that patients diagnosed with SMD or those undergoing antipsychotic treatment for less than one year may have elevated D-dimer levels, indicating a potential predisposition to VTE severity. This underscores the importance of recognizing VTE risk in individuals with severe mental disorders and warrants further investigation into the impact of antipsychotic treatment duration on thrombotic risk.

Keywords: asymptomatic thromboembolism, D-dimer, psychiatric disorder, risk factors


中文翻译：

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精神病住院患者无症状血栓栓塞的临床特征：回顾性研究

目的：静脉血栓栓塞 (VTE) 对个人健康构成重大威胁，但其与精神障碍的相关性仍未得到充分认识。在这里，我们进行了回顾性分析，以探讨出现 VTE 的精神病患者的特征。
方法：我们回顾性分析了2014年1月至2022年1月浙江大学医学院附属第一医院精神卫生中心血浆D-二聚体水平升高的精神科住院患者。纳入标准包括全面的人口统计学和临床​​资料，包括实验室和临床资料。影像学发现。
结果：纳入了 33 名符合条件的患者，血浆 D-二聚体水平为 880 至 10,700 μg/L FEU。与轻度精神障碍 (MMD)（包括抑郁症和焦虑症）患者相比，诊断为严重精神障碍 (SMD)（例如精神分裂症和双相情感障碍）的患者 D-二聚体水平显着升高（p = 0.007）。此外，与接受治疗一年以上的个体相比，接受抗精神病药物治疗不到一年的个体表现出 D-二聚体水平升高 (p = 0.005)。然而，D-二聚体水平的正常化并未证明与精神病学诊断或治疗持续时间存在显着相关性（p > 0.05）。
结论：我们的研究结果表明，诊断为 SMD 的患者或接受抗精神病药物治疗不到一年的患者 D-二聚体水平可能升高，表明存在 VTE 严重程度的潜在倾向。这强调了认识严重精神障碍患者 VTE 风险的重要性，并需要进一步研究抗精神病药物治疗持续时间对血栓风险的影响。

Keywords:无症状血栓栓塞, D-二聚体, 精神疾病, 危险因素