In this study we describe the electrophoretic deposition of mesoporous bioglass/hydroxyapatite/chitosan coatings on titanium substrate. Electrical conductivity and pH variation of solutions and suspensions using water/ethanol medium with different acetic acid concentrations were investigated. Based on zeta potential quantities and in-situ kinetics of deposition process, optimum amounts of acetic acid were achieved at 0.1 and 5%vol, respectively, for hydroxyapatite (HA) and mesoporous bioglass (MBG) suspensions containing chitosan (CS). Optimized amounts of acetic acid were used to prepare composite suspensions with various bioglass and hydroxyapatite concentrations of 20, 50 and 80%wt along with fixed concentration of CS. In order to tackle the bacterial infection in implant surgeries, MBG loaded with vancomycin as model antibiotic drug was used to prepare composite coatings. Among composite coatings, a sample containing 50%MBG and 50%HA presented maximum drug release with highest rate.

Graphical Abstract

中文翻译：

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电泳沉积三元壳聚糖/介孔生物玻璃/羟基磷灰石复合涂层用于药物输送

在这项研究中，我们描述了钛基底上介孔生物玻璃/羟基磷灰石/壳聚糖涂层的电泳沉积。研究了使用不同乙酸浓度的水/乙醇介质的溶液和悬浮液的电导率和pH变化。根据 zeta 电位量和沉积过程的原位动力学，对于含有壳聚糖 (CS) 的羟基磷灰石 (HA) 和介孔生物玻璃 (MBG) 悬浮液，乙酸的最佳用量分别为 0.1 和 5%vol。使用优化的乙酸量来制备复合悬浮液，其中生物玻璃和羟基磷灰石浓度分别为 20%、50% 和 80%wt，以及固定浓度的 CS。为了解决种植手术中的细菌感染问题，采用负载万古霉素作为模型抗生素药物的MBG制备复合涂层。在复合涂层中，含有50%MBG和50%HA的样品表现出最大的药物释放和最高的速率。

图形概要