The superb comprehensive mechanical properties of titanium and its alloys make them ideal materials for artificial bone repair. However, the osseointegration between normal tissue and implant is lengthy due to the relatively poor surface osteogenic bioactivity of titanium-based materials. For the sake of accelerating the bone healing process, surface modification for the titanium- based implant is therefore of great necessity. In this paper, the novel $\beta$-typed TiNb alloy with good biocompatibility was modified by a simple hydrothermal-precalcification method. The experimental results demonstrate that these hydrothermally prepared TiNb alloys were coated by a superhydrophilic Nb-doped TiO₂ film with a hierarchical micro-nanostructure. After subsequent pre-calcification treatment, calcium and phosphorus species with low content were successfully introduced into the film without morphological change. The simulated body fluid (SBF) soaking experiments show that the TiNb alloy with the two-step surface treatment represented excellent in vitro bioactivity. After incubating in SBF for only 1 day, the TiNb alloy surface was thoroughly coated with a layer of newly formed spherical hydroxyapatite clusters. Comparatively, no obvious hydroxyapatite was deposited on the TiNb alloy surface with the one-step hydrothermal treatment even after five days of incubation in SBF. As a result, the hydrothermal–precalcification treatment is an ideal method to improve the osteogenic bioactivity of TiNb alloy, which can be further extended to surface modification of other titanium-based implant materials.

钛及其合金优异的综合机械性能使其成为人工骨修复的理想材料。然而，由于钛基材料的表面成骨生物活性相对较差，正常组织与种植体之间的骨整合时间较长。因此，为了加速骨愈合过程，对钛基植入物进行表面改性是非常有必要的。在这篇论文中，小说$\beta$采用简单的水热预钙化方法对具有良好生物相容性的TiNb合金进行改性。实验结果表明，这些水热制备的TiNb合金表面涂覆有具有分级微纳结构的超亲水Nb掺杂TiO _2薄膜。经过后续的预钙化处理，低含量的钙和磷物质成功引入薄膜中，且形态没有发生变化。模拟体液（SBF）浸泡实验表明，经过两步表面处理的TiNb合金表现出优异的体外生物活性。在SBF中孵育仅1天后，TiNb合金表面就完全覆盖了一层新形成的球形羟基磷灰石簇。相比之下，经过一步水热处理的TiNb合金表面即使在SBF中培养5天也没有明显的羟基磷灰石沉积。因此，水热预钙化处理是提高TiNb合金成骨生物活性的理想方法，可进一步推广到其他钛基植入材料的表面改性。