Bradykinesia, a debilitating symptom characterized by impaired movement initiation and reduced speed in Parkinson’s disease (PD), is associated with abnormal oscillatory activity in the motor cortex-basal ganglia circuit. We investigated the interplay between abnormal beta and gamma oscillations in relation to bradykinesia in parkinsonian rats. Our findings showed reduced movement activities in parkinsonian rats, accompanied by enhanced high beta oscillations in the motor cortex, which are closely associated with movement transitional difficulties. Additionally, gamma oscillations correlated with movement velocity in control rats but not in parkinsonian rats. We observed selective coupling between high beta oscillation phase and gamma oscillation amplitude in PD, as well as cortical high beta-broadband gamma phase-amplitude coupling (PAC) negatively influencing locomotor activities in control and PD rats. These findings suggest a collaborative role of cortical beta and gamma oscillations in facilitating movement execution, with beta oscillations being linked to movement initiation and gamma oscillations associated with movement speed. Importantly, the aberrant alterations of these oscillations are closely related to the development of bradykinesia. Furthermore, PAC hold promise as a biomarker for comprehensive assessment of movement performance in PD.

中文翻译：

---

异常β和γ振荡对帕金森病大鼠运动迟缓的功能相互作用

运动迟缓是帕金森病 (PD) 中一种以运动起始受损和速度降低为特征的衰弱症状，与运动皮层基底神经节回路的异常振荡活动有关。我们研究了与帕金森病大鼠运动迟缓相关的异常β和γ振荡之间的相互作用。我们的研究结果表明，帕金森病大鼠的运动活动减少，并伴有运动皮层的高β振荡增强，这与运动过渡困难密切相关。此外，伽马振荡与对照大鼠的运动速度相关，但与帕金森病大鼠无关。我们观察到 PD 中高 β 振荡相位和 γ 振荡振幅之间的选择性耦合，以及皮质高 β 宽带 γ 相位振幅耦合 (PAC) 对对照和 PD 大鼠的运动活动产生负面影响。这些发现表明皮质β和γ振荡在促进运动执行方面发挥协同作用，β振荡与运动启动相关，而γ振荡与运动速度相关。重要的是，这些振荡的异常改变与运动迟缓的发展密切相关。此外，PAC 有希望作为全面评估 PD 运动表现的生物标志物。