To investigate the association between diabetic retinopathy (DR) and coronary artery disease (CAD) using coronary angiotomography (CCTA) and multimodal retinal imaging (MMRI) with ultra-widefield retinography and optical coherence tomography angiography and structural domain. Single-center, cross-sectional, single-blind. Patients with diabetes who had undergone CCTA underwent MMRI. Uni and multivariate analysis were used to assess the association between CAD and DR and to identify variables independently associated with DR. We included 171 patients, 87 CAD and 84 non-CAD. Most CAD patients were males (74 % vs 38 %, < 0.01), insulin users (52 % vs 38 %, < 0.01) and revascularized (64 %). They had a higher prevalence of DR (48 % vs 22 %, = 0.01), microaneurysms (25 % vs 13 %, = 0.04), intraretinal cysts (22 % vs 8 %, p = 0.01) and areas of reduced capillary density (46 % vs 20 %, p < 0.01). CAD patients also had lower mean vascular density (MVD) (15.7 % vs 16.5,%, = 0.049) and foveal avascular zone (FAZ) circularity (0.64 ± 0.1 vs 0.69 ± 0.1, p = 0.04). There were significant and negative correlations between Duke coronary score and MVD ( = −0.189; = 0.03) and FAZ circularity (r = −0,206; = 0.02). CAD, DM duration and insulin use independently associated with DR. CAD patients had higher prevalence of DR and lower MVD. CAD, DM duration and insulin use were independently associated with DR.

中文翻译：

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阻塞性冠状动脉疾病与糖尿病视网膜病变之间的关联：冠状动脉血管断层扫描和多模态视网膜成像的横断面研究

使用冠状动脉血管断层扫描 (CCTA) 和多模态视网膜成像 (MMRI) 以及超宽视野视网膜成像和光学相干断层扫描血管造影和结构域来研究糖尿病视网膜病变 (DR) 和冠状动脉疾病 (CAD) 之间的关联。单中心、横截面、单盲。接受 CCTA 的糖尿病患者接受了 MMRI。使用单变量和多变量分析来评估 CAD 和 DR 之间的关联，并确定与 DR 独立相关的变量。我们纳入了 171 名患者，其中 87 名 CAD 患者和 84 名非 CAD 患者。大多数 CAD 患者为男性（74% vs 38%，< 0.01）、胰岛素使用者（52% vs 38%，< 0.01）和血运重建患者（64%）。他们的 DR（48% vs 22%，= 0.01）、微动脉瘤（25% vs 13%，= 0.04）、视网膜内囊肿（22% vs 8%，p = 0.01）和毛细血管密度降低区域的患病率较高（ 46% 与 20%，p < 0.01）。 CAD 患者的平均血管密度 (MVD)（15.7% vs 16.5%, = 0.049）和中心凹无血管区 (FAZ) 圆形度也较低（0.64 ± 0.1 vs 0.69 ± 0.1，p = 0.04）。杜克冠状动脉评分与 MVD (= -0.189; = 0.03) 和 FAZ 循环度 (r = -0,206; = 0.02) 之间存在显着负相关。 CAD、DM 持续时间和胰岛素使用与 DR 独立相关。 CAD 患者 DR 患病率较高，MVD 较低。 CAD、DM 持续时间和胰岛素使用与 DR 独立相关。