Isoquinoline alkaloids are an important class of natural products that are abundant in the plant kingdom and exhibit a wide range of structural diversity and biological activities. With the deepening of research in recent years, more and more isoquinoline alkaloids have been isolated and identified and proved to contain a variety of biological activities and pharmacological effects. In this review, we introduce the research progress of isoquinoline alkaloids from 2019 to 2022, mainly in the part of biological activities, including antitumor, antimicrobial, antidiabetic, antiviral, anti-inflammatory, antioxidant, neuroprotective, hepatoprotective, analgesic, and other activities. This study provides a clear direction for the rational development and utilization of isoquinoline alkaloids, suggesting that these alkaloids have great potential in the field of drug research.

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2019-2022 年生物活性异喹啉生物碱

异喹啉生物碱是一类重要的天然产物，在植物界中含量丰富，具有广泛的结构多样性和生物活性。近年来随着研究的深入，越来越多的异喹啉类生物碱被分离鉴定，并被证明含有多种生物活性和药理作用。本文介绍了2019年至2022年异喹啉生物碱的研究进展，主要是生物活性部分，包括抗肿瘤、抗菌、抗糖尿病、抗病毒、抗炎、抗氧化、神经保护、保肝、镇痛等活性。该研究为异喹啉类生物碱的合理开发利用提供了明确的方向，表明此类生物碱在药物研究领域具有巨大的潜力。