Fructo-oligosaccharides (FOS) are often produced via enzymatic conversion in industry. Enzyme membrane bioreactor (EMBR) can enhance the catalytic efficiency by in-situ product removal. Its major bottleneck is the fouling caused by the deposition of enzyme on membrane surface. An EMBR system with a compact rotating disc device was established for continuous FOS production. This study further investigated the influences of the membrane rotation on the flux control and enzyme activity. The speed of 600 rpm was a good compromise between flux and fouling control, which stabilized the flux at ∼80 L m⁻²h⁻¹ during the process. Moreover, the rotation led to an increase in the rejection of enzymes by 20 %, compensating the loss of enzyme due to the inhomogeneous distribution of membrane pore size.

中文翻译：

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利用旋转陶瓷膜盘在膜生物反应器中生产低聚果糖 

工业中低聚果糖（FOS）通常通过酶促转化生产。酶膜生物反应器（EMBR）可以通过原位产物去除来提高催化效率。其主要瓶颈是酶在膜表面沉积造成的污染。建立了带有紧凑型转盘装置的 EMBR 系统，用于连续生产 FOS。本研究进一步研究了膜旋转对通量控制和酶活性的影响。600 rpm 的速度是通量和污垢控制之间的良好折衷，在此过程中将通量稳定在~80 L m ^-2 h ^-1。此外，旋转导致酶的截留率增加了 20%，补偿了由于膜孔径分布不均匀而造成的酶损失。