Background

Hepatic steatosis is characterized by lipid accumulation in hepatocytes. Cheong-sang-gyeon-tong-tang is a major prescription for all types of headaches in traditional East Asian medicine.

Objective

This study aimed to investigate the pharmacological effects of Cheong-sang-gyeon-tong-tang extract (CG) on high-fat diet (HFD)-induced hepatic steatosis in mice and to explore the underlying mechanism.

Results

Treatment with CG significantly reduced body weight, liver weight, and epididymal fat mass, as well as improved the serum and hepatic lipid profiles in the HFD-induced fatty liver mouse model. Further, CG alleviated lipid accumulation in HFD-fed mice by controlling lipid metabolism, including triglyceride and cholesterol synthesis, and fatty acid oxidation at the mRNA level. CG also regulated the expression of cholesterol regulatory proteins in HFD-induced fatty liver mice.

Conclusions

These results indicate that CG alleviates hepatic steatosis by regulating cholesterol homeostasis in HFD-induced fatty liver mice, thus improving our understanding of the mechanisms by which CG improves hepatic steatosis. Therefore, we propose CG as a therapeutic candidate for lipid metabolic disorders such as fatty liver disease.

中文翻译：

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清尚延汤汤通过调节胆固醇代谢改善肝脏脂肪变性

背景

肝脂肪变性的特征是肝细胞内脂质堆积。清桑绞痛汤是东亚传统医学中治疗各种头痛的主要处方。

客观的

本研究旨在探讨清桑根汤提取物（CG）对高脂饮食（HFD）诱导的小鼠肝脂肪变性的药理作用，并探讨其潜在机制。

结果

在 HFD 诱导的脂肪肝小鼠模型中，CG 治疗显着降低了体重、肝脏重量和附睾脂肪量，并改善了血清和肝脏脂质谱。此外，CG 通过控制脂质代谢（包括甘油三酯和胆固醇合成以及 mRNA 水平的脂肪酸氧化）来减轻 HFD 喂养小鼠的脂质积累。CG 还调节 HFD 诱导的脂肪肝小鼠中胆固醇调节蛋白的表达。

结论

这些结果表明，CG通过调节HFD诱导的脂肪肝小鼠的胆固醇稳态来减轻肝脏脂肪变性，从而提高我们对CG改善肝脏脂肪变性机制的理解。因此，我们建议 CG 作为脂质代谢紊乱（如脂肪肝疾病）的治疗候选药物。