Objective

Reproducibly define CPAP Belly Syndrome (CBS) in preterm infants and describe associated demographics, mechanical factors, and outcomes.

Study design

A retrospective case-control study was conducted in infants <32 weeks gestation in the Stanford Children’s NICU from January 1, 2020 to December 31, 2021. CBS was radiographically defined by a pediatric radiologist. Data analysis included descriptive statistics and comparator tests.

Results

Analysis included 41 infants with CBS and 69 infants without. CBS was associated with younger gestational age (median 27.7 vs 30 weeks, p < 0.001) and lower birthweight (median 1.00 vs 1.31 kg, p < 0.001). Infants with CBS were more likely to receive bilevel respiratory support and higher positive end expiratory pressure. Infants with CBS took longer to advance enteral feeds (median 10 vs 7 days, p = 0.003) and were exposed to more abdominal radiographs.

Conclusions

Future CBS therapies should target small infants, prevent air entry from above, and aim to reduce time to full enteral feeds and radiographic exposure.

中文翻译：

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新生儿重症监护病房 (NICU) 早产儿持续气道正压通气 (CPAP) 腹部综合征的特征

客观的

可重复地定义早产儿的 CPAP 腹部综合征 (CBS)，并描述相关的人口统计数据、机械因素和结果。

学习规划

2020 年 1 月 1 日至 2021 年 12 月 31 日，对斯坦福儿童新生儿重症监护病房 (Stanford Children's NICU) 的妊娠 <32 周的婴儿进行了一项回顾性病例对照研究。CBS 由儿科放射科医生通过放射学定义。数据分析包括描述性统计和比较测试。

结果

分析包括 41 名患有 CBS 的婴儿和 69 名未患有 CBS 的婴儿。CBS 与较小胎龄（中位 27.7 与 30 周， p  < 0.001）和较低出生体重（中位 1.00 与 1.31 kg，p < 0.001）相关 。患有 CBS 的婴儿更有可能接受双水平呼吸支持和较高的呼气末正压。患有 CBS 的婴儿需要更长的时间进行肠内喂养（中位时间为 10 天与 7 天，p  = 0.003），并且接受更多的腹部 X 光检查。

结论

未来的 CBS 疗法应针对小婴儿，防止空气从上方进入，并旨在减少完全肠内喂养和放射线照射的时间。