β-propeller protein-associated neurodegeneration (BPAN) is caused by loss of functional WIPI4. A new study reports that depletion of WIPI4 induces ferroptosis via changes in mitochondrial membrane lipids, independently of the role of WIPI4 in autophagy, providing insights into the cause of neurodegeneration in BPAN.

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WIPI4 缺失与铁死亡相关

β-螺旋桨蛋白相关神经变性 (BPAN) 是由 WIPI4 功能丧失引起的。一项新的研究报告称，WIPI4 的缺失会通过线粒体膜脂质的变化诱导铁死亡，这与 WIPI4 在自噬中的作用无关，这为 BPAN 神经变性的原因提供了见解。