Abstract

The mechanism of biological activity of various sulfur-containing compounds and sulfur fragments of both natural and synthetic origins is presented. Unique characteristics of organosulfur compounds that are present in natural plant products are considered to reveal the most efficient sulfur components of the natural origin. An insufficient efficiency of the pharmacological action of plant raw materials and undesirable effects indisputably confirm the topical character of research on the preparation of modified analogs of natural biologically active sulfur-containing compounds. The modern data on the development of new polytopic organosulfur compounds combining different redox-active functional groups in the structure, which should favor their efficiency and a decrease in side manifestations, are reviewed. Sulfur-containing metal complexes with antimicrobial, antiviral, and anticancer properties are among the most promising pharmacologically active compounds. In spite of the success achieved in this field of chemistry, the preparation of new target-oriented biodrugs based on bioessential metals (Cu, Zn, Se) and biomimetic organosulfur fragments remains to be an urgent problem. The developments in this direction should favor to understand mechanisms of the therapeutic action of new drugs and to prepare drugs of the new generation followed by their implementation in clinical practice.

中文翻译：

---

有机硫衍生物及其金属配合物作为有前景的药理活性化合物

摘要

介绍了天然和合成来源的各种含硫化合物和硫片段的生物活性机制。天然植物产品中存在的有机硫化合物的独特特性被认为揭示了天然来源的最有效的硫成分。植物原料的药理作用效率不足和不良反应无可争议地证实了制备天然生物活性含硫化合物的修饰类似物的研究的主题特征。综述了在结构中结合不同氧化还原活性官能团的新型多位有机硫化合物的开发的现代数据，这应该有利于它们的效率和减少副作用。具有抗菌、抗病毒和抗癌特性的含硫金属配合物是最有前途的药理活性化合物之一。尽管在这一化学领域取得了成功，但基于生物必需金属（铜、锌、硒）和仿生有机硫片段制备新型靶向生物药物仍然是一个紧迫的问题。这个方向的发展应有利于了解新药的治疗作用机制，并制备新一代药物，然后将其应用于临床实践。