Impairments of the sleep architecture due to disrupted sleep in individuals with obstructive sleep apnea (OSA) may result in reduced slow wave sleep (SWS), intermittent hypoxemia, and excessive day time sleepiness— all factors that have been shown to impact Alzheimer’s disease (AD) risk. In this commentary, we comment on the work by Cavuoto and colleagues in which they examine the associations between nocturnal hypoxemia or sleep disruptions (during SWS) and amyloid-β burden in individuals with OSA. We review the findings in the context of other similar studies and highlight the strengths and weaknesses of these published studies. We note the importance of examining these relationships longitudinally with a large sample size, including considering sleep health disparities, vascular components, and multiple cognitive domain tests.

中文翻译：

---

阻塞性睡眠呼吸暂停和阿尔茨海默病病理学：睡眠结构是缺失的关键吗？

患有阻塞性睡眠呼吸暂停 (OSA) 的人因睡眠中断而导致的睡眠结构受损，可能会导致慢波睡眠 (SWS) 减少、间歇性低氧血症和白天过度嗜睡——所有这些因素已被证明会影响阿尔茨海默病 (AD) ） 风险。在这篇评论中，我们对 Cavuoto 及其同事的工作进行了评论，他们研究了 OSA 患者夜间低氧血症或睡眠中断（在 SWS 期间）与淀粉样蛋白 - β 负担之间的关联。我们在其他类似研究的背景下回顾了这些发现，并强调了这些已发表研究的优点和缺点。我们注意到以大样本量纵向研究这些关系的重要性，包括考虑睡眠健康差异、血管成分和多个认知领域测试。