How do passing moments turn into lasting memories? Sheltered from external tasks and distractions, sleep constitutes an optimal state for the brain to reprocess and consolidate previous experiences. Recent work suggests that consolidation is governed by the intricate interaction of slow oscillations (SOs), spindles, and ripples – electrophysiological sleep rhythms that orchestrate neuronal processing and communication within and across memory circuits. This review describes how sequential SO–spindle–ripple coupling provides a temporally and spatially fine-tuned mechanism to selectively strengthen target memories across hippocampal and cortical networks. Coupled sleep rhythms might be harnessed not only to enhance overnight memory retention, but also to combat memory decline associated with healthy ageing and neurodegenerative diseases.

中文翻译：

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耦合睡眠节律可巩固记忆

逝去的瞬间如何变成永恒的回忆？睡眠免受外部任务和干扰的影响，是大脑重新处理和巩固先前经历的最佳状态。最近的研究表明，巩固是由慢振荡（SO）、纺锤体和波纹的复杂相互作用控制的，这些电生理睡眠节律协调记忆回路内部和之间的神经元处理和通信。这篇综述描述了顺序 SO-纺锤体-波纹耦合如何提供一种时间和空间微调机制，以选择性地加强海马和皮质网络的目标记忆。耦合睡眠节律不仅可以用来增强夜间记忆保留，还可以用来对抗与健康衰老和神经退行性疾病相关的记忆衰退。