Phosphorylation of α-synuclein protein at serine-129 (Ser129P) is a widely used marker for disease pathology in neurodegenerative disorders termed synucleinopathies. In groundbreaking work by Ser129P was shown to facilitate the normal function of α-synuclein, bearing significant implications for the transition from a physiological to pathological state.

中文翻译：

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控制神经元活动：α-突触核蛋白丝氨酸 129 磷酸化在健康大脑中的新作用

α-突触核蛋白丝氨酸 129 (Ser129P) 的磷酸化是神经退行性疾病（称为突触核蛋白病）中广泛使用的疾病病理学标记物。 Ser129P 的开创性工作被证明可以促进 α-突触核蛋白的正常功能，对从生理状态到病理状态的转变具有重要意义。