Abstract

The review is devoted to the mechanisms of free radical lipid peroxidation (LPO) initiated by reactive halogen species (RHS) produced in mammals, including humans, by heme peroxidase enzymes, primarily myeloperoxidase (MPO). It has been shown that RHS can participate in LPO both in the initiation and branching steps of the LPO chain reactions. The initiation step of RHS-induced LPO mainly involves formation of free radicals in the reactions of RHS with nitrite and/or with amino groups of phosphatidylethanolamine or Lys. The branching step of the oxidative chain is the reaction of RHS with lipid hydroperoxides, in which peroxyl and alkoxyl radicals are formed. The role of RHS-induced LPO in the development of human inflammatory diseases (cardiovascular and neurodegenerative diseases, cancer, diabetes, rheumatoid arthritis) is discussed in detail.

中文翻译：

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活性卤素诱导的自由基脂质过氧化

摘要

该综述致力于研究由血红素过氧化物酶（主要是髓过氧化物酶 (MPO)）在哺乳动物（包括人类）中产生的活性卤素物质 (RHS) 引发的自由基脂质过氧化 (LPO) 机制。研究表明，RHS 可以参与 LPO 链式反应的引发和支化步骤。RHS诱导的LPO的起始步骤主要涉及RHS与亚硝酸盐和/或与磷脂酰乙醇胺或Lys的氨基反应中自由基的形成。氧化链的分支步骤是RHS与脂质氢过氧化物的反应，其中形成过氧自由基和烷氧基自由基。详细讨论了 RHS 诱导的 LPO 在人类炎症性疾病（心血管和神经退行性疾病、癌症、糖尿病、类风湿性关节炎）发展中的作用。