Medication adherence is vital for patients suffering from Chronic Obstructive Pulmonary Disease (COPD) to mitigate long-term consequences. The impact of poor medication adherence on inferior outcomes like exacerbations leading to hospital admissions is yet to be studied using real-world data. Using Swiss claims data from 2015-2020, we group patients into five categories according to their medication possession ratio. By employing a logistic regression, we quantify each category’s average treatment effect of the medication possession ratio on hospitalized exacerbations. 13,557 COPD patients are included in the analysis. Patients with high medication adherence (daily medication reserve of 80% to 100%) are 51% less likely to incur exacerbation following a hospital stay than patients with the lowest medication adherence (daily medication reserve of 0% to 20%). The study shows that medication adherence varies strongly among Swiss COPD patients. Furthermore, high medication adherence immensely decreases the risk of hospitalized exacerbations.

对于患有慢性阻塞性肺疾病 (COPD) 的患者来说，坚持用药对于减轻长期后果至关重要。药物依从性差对不良结果（例如病情恶化导致入院）的影响尚未使用真实世界数据进行研究。利用 2015 年至 2020 年瑞士的索赔数据，我们根据患者的药物持有率将患者分为五类。通过采用逻辑回归，我们量化了每个类别的药物持有率对住院病情加重的平均治疗效果。分析中纳入了 13,557 名慢性阻塞性肺病 (COPD) 患者。与药物依从性最低的患者（每日药物储备为 0% 至 20%）相比，药物依从性高（每日药物储备为 80% 至 100%）的患者住院后病情恶化的可能性要低 51%。研究表明，瑞士慢性阻塞性肺病患者的药物依从性差异很大。此外，高药物依从性极大地降低了住院病情加重的风险。