Abstract

Worldwide, endometrial cancer is one of the most frequently diagnosed malignancies in women and a notable cause of death. The aim of this study was to perform image cytometric DNA ploidy analysis on a prospective material of endometrial adenocarcinomas in order to determine potential correlation between ploidy status and their histological features. The analysis was carried out in fresh tissue samples resected by implementing complete hysterectomy in a series of patients (n = 126). We found that ploidy status using image cytometry correlate with histologic type, grade and stage in endometrial cancer and aneuploid tumor samples are associated with aggressive phenotype statistics. Furthermore, DNA ploidy should be used as a reliable and applicable prognostic marker in the routine clinical practice.

中文翻译：

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基于图像细胞术研究不同DNA倍体模式对子宫内膜癌的影响

摘要

在世界范围内，子宫内膜癌是女性最常诊断的恶性肿瘤之一，也是重要的死亡原因。本研究的目的是对子宫内膜腺癌的前瞻性材料进行图像细胞计数 DNA 倍性分析，以确定倍性状态与其组织学特征之间的潜在相关性。该分析是在一系列患者 ( n = 126) 中实施完整子宫切除术而切除的新鲜组织样本中进行的。我们发现使用图像细胞术的倍性状态与子宫内膜癌的组织学类型、分级和阶段相关，并且非整倍体肿瘤样本与侵袭性表型统计相关。此外，DNA倍体应在常规临床实践中作为可靠且适用的预后标志物。