Resistant hypertension (RH) is characterized by persistently elevated blood pressure despite the concurrent use of three antihypertensive medications, including a diuretic, at optimal doses. This clinical phenomenon poses a significant burden on healthcare systems worldwide due to its association with increased cardiovascular disease morbidity and mortality.

中文翻译：

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抵抗性高血压。

顽固性高血压（RH）的特点是尽管以最佳剂量同时使用包括利尿剂在内的三种抗高血压药物，但血压持续升高。由于这种临床现象与心血管疾病发病率和死亡率增加有关，因此给全世界的医疗保健系统带来了沉重负担。