Chimeric antigen receptor (CAR‐T) cell therapy is a newly developed immunotherapy strategy and has achieved satisfactory outcomes in the treatment of hematological malignancies. However, some adverse effects related to CAR‐T cell therapy have to be resolved before it is widely used in clinics as a cancer treatment. Furthermore, the application of CAR‐T cell therapy in the treatment of solid tumors has been hampered by numerous limitations. Therefore, it is essential to explore novel strategies to improve the therapeutic effect of CAR‐T cell therapy. In this review, we summarized the recently developed strategies aimed at optimizing the generation of CAR‐T cells and improving the anti‐tumor efficiency of CAR‐T cell therapy. Furthermore, the discovery of new targets for CAR‐T cell therapy and the combined treatment strategies of CAR‐T cell therapy with chemotherapy, radiotherapy, cancer vaccines and nanomaterials are highlighted.

中文翻译：

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提高CAR-T细胞疗法免疫治疗效果的先进策略

嵌合抗原受体（CAR-T）细胞疗法是一种新发展的免疫治疗策略，在血液恶性肿瘤的治疗中取得了令人满意的效果。然而，在广泛应用于临床作为癌症治疗方法之前，必须解决与 CAR-T 细胞疗法相关的一些副作用。此外，CAR-T细胞疗法在实体瘤治疗中的应用受到许多限制的阻碍。因此，有必要探索新的策略来提高CAR-T细胞疗法的治疗效果。在这篇综述中，我们总结了最近开发的旨在优化 CAR-T 细胞生成和提高 CAR-T 细胞疗法的抗肿瘤效率的策略。此外，还重点介绍了CAR-T细胞治疗新靶点的发现以及CAR-T细胞治疗与化疗、放疗、癌症疫苗和纳米材料的联合治疗策略。