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Aerobic glycolysis comes with an enzyme cost but robustness gain
Nature Chemical Biology ( IF 14.8 ) Pub Date : 2024-03-08 , DOI: 10.1038/s41589-024-01581-w


The rate of ATP production and the total mass of enzymes were quantified for both glycolysis and mitochondrial respiration to determine the proteome efficiency of these pathways. Per unit of enzyme mass, mitochondrial respiration generates energy faster than glycolysis and is thus more proteome efficient. Despite being less proteome efficient, constitutive glycolysis comes with the benefit of rendering cells robust to hypoxia.

中文翻译:

有氧糖酵解会消耗酶,但会增加稳定性

对糖酵解和线粒体呼吸的 ATP 产生速率和酶的总质量进行量化,以确定这些途径的蛋白质组效率。每单位酶质量,线粒体呼吸产生能量的速度比糖酵解更快,因此蛋白质组效率更高。尽管蛋白质组效率较低,但组成型糖酵解具有使细胞对缺氧具有抵抗力的好处。
更新日期:2024-03-10
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