Abstract

Evidence has revealed that DDOST plays an important role in cancer development and progression. However, there are no reports on functions of DDOST in cervical tumorigenesis. Hence, we investigated the relationship of DDOST with prognosis, mutation, promoter methylation, immune cell infiltration, and drug sensitivity using bioinformatics techniques. Our results demonstrated that DDOST was significantly upregulated in a variety of tumor types and correlated with poor prognosis, including cervical cancer. Cox regression analysis dissected that high DDOST expression was associated with poor survival in cervical cancer patients. Immune infiltration analysis defined that DDOST was negatively correlated with CD8 T cells and NK cells. Strikingly, the sensitivity to multiple drugs was negatively correlated with the expression of DDOST. Therefore, our findings uncovered that DDOST could play an essential role in the tumor microenvironment and tumor immune regulation in cervical cancer, which indicated that DDOST could be a useful biomarker for prognosis and a potential therapeutic target for cancer treatment.

中文翻译：

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DDOST与宫颈癌肿瘤免疫抑制微环境相关

摘要

有证据表明，DDOST 在癌症的发生和进展中发挥着重要作用。但DDOST在宫颈肿瘤发生中的作用尚未见报道。因此，我们利用生物信息学技术研究了 DDOST 与预后、突变、启动子甲基化、免疫细胞浸润和药物敏感性的关系。我们的结果表明，DDOST 在多种肿瘤类型中显着上调，并与不良预后相关，包括宫颈癌。Cox 回归分析表明，DDOST 高表达与宫颈癌患者生存率低相关。免疫浸润分析表明DDOST与CD8 T细胞和NK细胞呈负相关。引人注目的是，对多种药物的敏感性与 DDOST 的表达呈负相关。因此，我们的研究结果表明，DDOST在宫颈癌的肿瘤微环境和肿瘤免疫调节中发挥着重要作用，这表明DDOST可能是一种有用的预后生物标志物和癌症治疗的潜在治疗靶点。