Pdgfrα stromal cells are a group of cells specifically expressing Pdgfrα, which may be mentioned with distinct names in different tissues. Importantly, the findings from numerous studies suggest that these cells share exactly similar biomarkers and properties, show complex functions in regulating the microenvironment, and are critical to tissue regeneration, repair, and degeneration. Comparing the similarities and differences between distinct tissue-resident Pdgfrα stromal cells is helpful for us to more comprehensively and deeply understand the behaviors of these cells and to explore some common regulating mechanisms and therapeutical targets. In this review, we summarize previous and current findings on Pdgfrα stromal cells in various tissues and discuss the crosstalk between Pdgfrα stromal cells and microenvironment.

中文翻译：

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Pdgfrα+ 基质细胞，不同器官组织稳态和功能障碍的关键调节因子

Pdgfrα基质细胞是一组特异性表达Pdgfrα的细胞，在不同的组织中可能有不同的名称。重要的是，大量研究的结果表明，这些细胞具有完全相同的生物标志物和特性，在调节微环境方面表现出复杂的功能，并且对组织再生、修复和退化至关重要。比较不同组织驻留的Pdgfrα基质细胞之间的异同，有助于我们更全面、更深入地了解这些细胞的行为，并探索一些共同的调节机制和治疗靶点。在这篇综述中，我们总结了各种组织中 Pdgfrα 基质细胞的先前和当前研究结果，并讨论了 Pdgfrα 基质细胞与微环境之间的串扰。