Previous research has indicated that preoperative beta blocker therapy is associated with a decreased risk of complications after surgery for rectal cancer. This is thought to arise because of the anti-inflammatory activity of the drug. These results need to be reproduced and analyses extended to other drugs with such properties, as this information might be useful in clinical decision-making. The main aim of this work was to replicate previous findings of beta blocker use as a prognostic marker for postoperative leakage. We also investigated whether drug exposure might induce anastomotic leaks.

中文翻译：

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术前β受体阻滞剂和其他药物与直肠癌前切除术后吻合口瘘的关系

先前的研究表明，术前β受体阻滞剂治疗可降低直肠癌术后并发症的风险。这被认为是由于该药物的抗炎活性而产生的。这些结果需要重现，并将分析扩展到具有此类特性的其他药物，因为这些信息可能对临床决策有用。这项工作的主要目的是复制之前使用β受体阻滞剂作为术后渗漏预后标志物的发现。我们还调查了药物暴露是否可能引起吻合口渗漏。