The role of fractional flow reserve (FFR) in coronary intermediate lesions is widely recommended by guidelines. The effect of uric acid (UA) on cardiovascular events is also well known. However, the relationship between UA and long-term cardiovascular outcomes in patients who received FFR with intermediate lesions remains unknown. We retrospectively included 428 patients who underwent both coronary angiography (CAG) and FFR. Participants were stratified into two groups based on the median UA. The primary endpoint was the composite of major adverse cardiovascular and cerebrovascular events (MACCEs), including repeat revascularization, nonfatal stroke, nonfatal myocardial infarction, and all-cause death. A Cox proportional hazards model was utilized to analyze the association between UA and the prevalence of MACCEs. During a median follow-up of 5.8 years, a higher MACCEs rate occurred in the high UA group compared to the low UA group (16.8% vs. 5.1%, log-rank<0.01). Elevated UA was independently linked to a higher incidence of MACCEs, whether UA was treated as a categorical or continuous variable (hazard ratio [HR] 2.76, 95% confidence interval [CI] 1.27–6.03 or HR 1.01, 95% CI 1.01–1.02). The restricted cubic spline (RCS) analysis illustrated that the HR for MACCEs increased with increasing UA. The present study demonstrates that UA is associated with MACCEs risk and suggests that UA is a reliable predictor of long-term cardiovascular events in coronary intermediate stenosis patients.

中文翻译：

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对于接受部分血流储备并伴有冠状动脉中间狭窄的患者，高尿酸水平与长期不良心血管结局相关

指南广泛推荐血流储备分数（FFR）在冠状动脉中间病变中的作用。尿酸（UA）对心血管事件的影响也是众所周知的。然而，对于接受 FFR 治疗且有中间病变的患者，UA 与长期心血管结局之间的关系仍不清楚。我们回顾性纳入了 428 名接受冠状动脉造影 (CAG) 和 FFR 的患者。根据 UA 中位数，将参与者分为两组。主要终点是主要不良心脑血管事件（MACCE）的复合，包括重复血运重建、非致命性卒中、非致命性心肌梗死和全因死亡。利用 Cox 比例风险模型分析 UA 与 MACCE 患病率之间的关联。在中位随访 5.8 年期间，与低 UA 组相比，高 UA 组的 MACCE 发生率更高（16.8% vs. 5.1%，对数秩<0.01）。无论 UA 被视为分类变量还是连续变量，UA 升高与 MACCE 发生率较高独立相关（风险比 [HR] 2.76，95% 置信区间 [CI] 1.27–6.03 或 HR 1.01，95% CI 1.01–1.02 ）。限制三次样条 (RCS) 分析表明，MACCE 的 HR 随着 UA 的增加而增加。本研究表明，UA 与 MACCE 风险相关，并表明 UA 是冠状动脉中度狭窄患者长期心血管事件的可靠预测因子。