Odontogenic tumors a variety of benign and malignant lesions developed exclusively in the jaws. They are known to have variable clinical behaviors and different histological features. The development of odontogenic tumors is attributed to alterations in some genetic and biological molecules. The aim of this study is to assess Glypican-3 immune expression in different groups of odontogenic neoplasms as in Ameloblastoma, Ameloblastic Fibroma, and Ameloblastic Carcinoma, and compare it to dental follicle tissue as control group. Also correlate the marker expression with the known biological behavior of these tumors. This study included 40 cases were selected from oral and maxillofacial pathology department (ten cases in each group). Some sections are prepared to be stained with H&E stain and other sections with Glypican-3 immune stain. Histological examination and Histomorphometric analysis were done finally under light microscope. The area percents of Glypican-3 immune expression in all tumor sections were measured. Level of expression of Glypican-3 revealed significant difference between the study groups (P-value < or = 0.05). The level of immune expression was highest in ameloblastic carcinoma group (M = 58.7) followed by ameloblastoma group (M = 33.9), then ameloblastic fibroma (M = 5.6) and lowest in the control group of dental follicle (M = 1.3). Glypican-3 immune expression demonstrated statistically significant difference among the study groups, indicating that it may have contributing role in tumor pathogenesis and its biological behavior.

中文翻译：

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成釉细胞瘤、成釉细胞纤维瘤、成釉细胞癌中磷脂酰肌醇蛋白聚糖 3 免疫表达的评估（试点研究）

牙源性肿瘤是仅在颌骨中发生的各种良性和恶性病变。已知它们具有可变的临床行为和不同的组织学特征。牙源性肿瘤的发生归因于一些遗传和生物分子的改变。本研究的目的是评估不同组的牙源性肿瘤（如成釉细胞瘤、成釉细胞纤维瘤和成釉细胞癌）中 Glypican-3 的免疫表达，并将其与作为对照组的牙囊组织进行比较。还将标记物表达与这些肿瘤的已知生物学行为相关联。本研究选取口腔颌面部病理科患者40例（每组10例）。一些切片准备用 H&E 染色剂染色，其他切片则用 Glypican-3 免疫染色剂染色。最后在光学显微镜下进行组织学检查和组织形态学分析。测量所有肿瘤切片中 Glypican-3 免疫表达的面积百分比。Glypican-3 的表达水平显示研究组之间存在显着差异（P 值 < 或 = 0.05）。成釉细胞癌组免疫表达水平最高（M = 58.7），其次是成釉细胞瘤组（M = 33.9），然后是成釉细胞纤维瘤组（M = 5.6），牙囊对照组免疫表达水平最低（M = 1.3）。Glypican-3免疫表达在研究组之间表现出统计学上的显着差异，表明它可能在肿瘤发病机制及其生物学行为中发挥作用。