Clinical and histologic examination of a 12-y-old client-owned Quarter Horse gelding with pituitary pars intermedia dysfunction revealed dermatitis, cellulitis, and osteomyelitis caused by Aspergillus nidulans, confirmed by a PCR assay. This novel presentation of a fungal disease in a horse was characterized by aggressive local invasion and failure to respond to all medical therapy attempted over a 1-y period. Treatments included systemic and topical antifungals, anti-inflammatories, and use of cellular matrices. Surgical excision was not attempted but should be strongly considered early in the disease process in similar cases if clean margins can be achieved. Postmortem findings were of locally aggressive disease with no dissemination.

中文翻译：

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垂体中间部功能障碍的马由构巢曲霉引起的皮炎、蜂窝织炎和骨髓炎

客户拥有的一匹患有垂体中间部功能障碍的 12 岁夸特马骟马的临床和组织学检查显示，由构巢曲霉引起的皮炎、蜂窝组织炎和骨髓炎，经 PCR 检测证实。马匹真菌疾病的这种新表现的特点是侵袭性局部侵袭，并且在一年内尝试的所有药物治疗均无效。治疗包括全身和局部抗真菌药、抗炎药以及使用细胞基质。未尝试手术切除，但如果可以实现干净的边缘，在类似病例的疾病过程早期应强烈考虑进行手术切除。尸检结果显示疾病呈局部侵袭性，没有传播。